Mengyuan Kan

A clear mind brings blessings~

Integrative Omics Studies of Respiratory Diseases

43.Kan M, Himes B. Insights into Glucocorticoid Responses Derived from Omics Studies. Pharmacol Ther [in press] PMID: 32910934

42.Diwadkar AR, Kan M, Himes BE. Facilitating Analysis of Publicly Available ChIP-Seq Data for Integrative Studies. AMIA Annu Symp Proc. 2020 Mar 4;2019:371-379. Received AMIA 2019 Distinguished Paper Award. PMID: 32308830

41.Kan M, Koziol-White C, Shumyatcher M, Johnson M, Jester W, Panettieri RA Jr, Himes BE. Airway Smooth Muscle-Specific Transcriptomic Signatures of Glucocorticoid Exposure. Am J Respir Cell Mol Biol. 2019 61(1):110-120. PMID: 30694689

40.Kan M, Shumyatcher M, Diwadkar AR, Soliman G, Himes BE. Integration of Transcriptomic Data Identifies Global and Cell-Specific Asthma-Related Gene Expression Signatures. AMIA Annu Symp Proc. 2018 Dec 5;2018:1338-1347. Finalist of AMIA Student Paper Award. PMID: 30815178

39.Kan M, Shumyatcher M, Himes B. Using omics approaches to understand pulmonary diseases. Respir Res. 2017 18(1):149. PMID: 28774304


Asthma Genetics and Pharmacogenetics

38.Kan M, Himes BE. Genetics and Pharmacogenetics of Asthma. Precision Therapy in Pulmonary, Critical Care and Sleep Medicine. Gomez JL, Himes BE, Kaminski N (eds). 1st ed. Springer, New York, NY. 2020. Chapter 3: 25-37p.

37.Dahlin A, Sordillo JE, Ziniti J, Iribarren C, Lu M, Weiss ST, Tantisira KG, Lu Q, Kan M, Himes BE, et al. Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults. J Allergy Clin Immunol 2019 143(4):1633-1635. PMID: 30578877

36.Panganiban R, Sun M, Dahlin A, Park H, Kan M, Himes BE, et al. A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis. J Allergy Clin Immunol. 2018 142(5):1469-1478. PMID: 29330013


Applications of Our Open-source Tools

35.Xu Y, Zhang Y, Garcia-Canaveras JC, Guo L, Kan M, Yu S, Blair IA, Rabinowitz JD, X Yang. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 Jul 24;369(6502):397-403. PMID: 32703873

34.Balamuth F, Alpern ER, Kan M, Shumyatcher M, Hayes K, Lautenbach E, Himes BE. Gene Expression Profiles Differentiate Viral from Bacterial Source Pathogen in Children with Suspected Sepsis in the Emergency Department. Ann Emerg Med. 2020 Jun;75(6):744-754. PMID: 31983492


NHLBI Exome Sequencing Project (ESP): Rare Variant Association Studies

33.Kan M, Auer PL, Wang GT, Bucasas KL, Hooker S, Rodriguez A, Li B, Ellis J, Cupples LA, Chen YD, et al. Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project. Eur J Hum Genet. 2016 24(8):1181-7. PMID: 26757982

32.He Z, O’Roak BJ, Smith JD, Wang G, Hooker S, Santos-Cortez RL, Li B, Kan M, Krumm N, Nickerson DA, et al. Rare-variant extensions of the transmission disequilibrium test: application to autism exome sequence data. Am J Hum Genet. 2014 94:33-46. PMID: 24360806

NHLBI-ESP Consortium Publications

31.Rosenthal EA et al. Rare loss of function variants in candidate genes and risk of colorectal cancer. Hum Genet. 2018 137(10):795-806. PMID: 30267214

30.Auer PL et al. Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. JAMA Neurol. 2015 72:781-788, 2015. PMID: 25961151

29.Do R et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015 518:102-106. PMID: 25487149

28.Tabor HK et al. Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results. Am J Hum Genet 95:183-193, 2014. PMID: 25087612

27.Lange LA et al. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 2014 94:233-245. 24507775

26.Rosenthal EA et al. Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. Am J Hum Genet. 2013 93:1035-1045. PMID: 24268658

25.Guo DC et al. Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet. 2013 93:398-404. PMID: 23910461

24.Johnsen JM et al. Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project. Blood. 2013 122:590-597. PMID: 23690449

23.Norton N et al. Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circ Cardiovasc Genet. 2013 6:144-153. 23418287

22.Fu W et al. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature. 2013 493:216-220. PMID: 23201682

21.Boileau C et al. TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nat Genet. 2012 44:916-921. PMID: 22772371

20.Emond MJ et al. Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Nat Genet. 2012 44:886-889. PMID: 22772370


Cancer Genomics and Epigenomics

19.Zhang L, Kan M*, Zhang M, Yu S, Xie H, Gu Z, Wang H, Zhao S, Zhou G, Song H, Zheng C. Multiregion sequencing reveals intratumor heterogeneity of driver mutations in TP53-driven non-small cell lung cancer. Int J Cancer. 2017 140(1):103-10. PMID: 27646734

18.Liu F, Zhou Y, Zhou D, Kan M, Niu X, Zhang Z, Zhang D, Tao L, He L, Zhang L, Liu Y. Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition. Diagnosis Pathology. 2014 9:66. PMID: 24655585


Next Generation Sequencing Application

17.Wu C, Zhang D, Kan M*, Lv Z, Zhu A, et al. The draft genome of the large yellow croaker reveals well-developed innate immunity. Nat Commun. 2014 5:5227. PMID: 25407894


Genetic and Epigenetic Studies in Chinese Population

16.Weng X, Liu F, Zhang H, Kan M, Wang T, Dong M, Liu Y. Genome-wide DNA methylation profiling in infants born to gestational diabetes mellitus. Diabetes Res Clin Pract. 2018 142:10-18. PMID: 26049047

15.Weng X, Zhang H, Kan M*, Ye J, Liu F, et al. Leukocyte telomere length is associated with advanced age-related macular degeneration in the Han Chinese population. 2015. Exp Gerontol 69:36-40. PMID: 25959250

14.Weng X, Zhang H, Ye J, Kan M, Liu F et al. Hypermethylated Epidermal growth factor receptor (EGFR) promoter is associated with gastric cancer. 2015 Sci Rep 5:10154. PMID: 25959250

13.Kan M, Weng X, Wang T, Liu F, Ye J, et al. No evidence of association between variant rs2075650 in lipid metabolism-related locus APOE/TOMM40 and advanced age-related macular degeneration in Han Chinese population. Exp Biol Med (Maywood). 2015 240:230-234. PMID: 25304313

12.Kan M, Liu F, Weng X, Ye J, Wang T, et al. Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population. Diagn Pathol. 2014 9:73. PMID: 24667176

11.Qian D, Kan M*, Weng X, Huang Y, Zhou C, et al. Common variant rs10033900 near the complement factor I gene is associated with age-related macular degeneration risk in Han Chinese population. Eur J Hum Genet. 2014 22:1417-1419. PMID: 24642830

10.Weng X, Zhou D, Liu F, Zhang H, Ye J, Zhang Z, Zhang D, Wang Y, Tao L, Cao L, Kan M et al. DNA methylation profiling in the thalamus and hippocampus of postnatal malnourished mice, including effects related to long-term potentiation. BMC Neurosci. 2014 15:31. PMID: 24555847

9.Niu X, Li H, Chen Z, Liu Y, Kan M et al. A study of ethnic differences in TGFbeta1 gene polymorphisms and effects on the risk of radiation pneumonitis in non-small-cell lung cancer. J Thorac Oncol. 2012 7:1668-1675. PMID: 23059779

8.Tao L, Zhang Z, Chen Z, Zhou D, Li W, Kan M et al. A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population. Mol Biol Rep. 2012 39:6487-6493. 22350153

7.Shen Q, Zhao X, Yu L, Zhang Z, Zhou D, Kan M et al. Association of leukocyte telomere length with type 2 diabetes in mainland Chinese populations. 2012 J Clin Endocrinol Metab 97:1371-1374. PMID: 22319045

6.Zheng Y, Kan M*, Yu L, Niu X, Zhou D, He L, Lu S, Liu Y. GPC5 rs2352028 polymorphism and risk of lung cancer in Han Chinese. 2012 Cancer Invest 30:13-19. PMID: 22236185

5.Chen G, Zhou D, Zhang Z, Kan M, Zhang D et al. Genetic variants in IFIH1 play opposite roles in the pathogenesis of psoriasis and chronic periodontitis. Int J Immunogenet. 2012 39:137-143. PMID: 22152027

4.Zhang Z, Tao L, Chen Z, Zhou D, Kan M et al. Association of genetic loci with blood lipids in the Chinese population. 2011 PLoS One 6:e27305. PMID: 22073310

3.Shen Q, Zhang Z, Yu L, Cao L, Zhou D, Kan M et al. Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population. Eur J Hum Genet. 2011 19:721-723. PMID: 21304559

2.Kan MY, Zhou DZ, Zhang D, Zhang Z, Chen Z, et al. Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort. Diabet Med. 2010 27:598-602. PMID: 20536959

1.Zhou DZ, Liu Y, Zhang D, Liu SM, Yu L, Yang YF, Zhao T, Chen Z, Kan MY et al. Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese. J Hum Genet. 2010 55:810-815. PMID: 20927120




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