Mengyuan Kan

A clear mind brings blessings~

Selected Peer-reviewed Publications

You can find the complete list of my published work in NIH MyBibliography

* indicates co-first authored papers

Multiomics Integration

Kan M, Diwadkar AR, Shuai H, Joo J, Wang AL, Ong MS, Sordillo JE, et al. Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene. J Allergy Clin Immunol. 2022 Jun;149(6):1981-1991. PMID: 34971648

Kan M, Sun M, Jiang X, Diwadkar AR, Parikh V, Cao G, Gebski E, Jester W, Lan B, Panettieri RA Jr, Koziol-White C, Lu Q, Himes BE. CEBPD modulates the airway smooth muscle transcriptomic response to glucocorticoids. Respir Res. 2022 Jul 28;23(1):193. PMID: 35902923

Kan M, Koziol-White C, Shumyatcher M, Johnson M, Jester W, Panettieri RA Jr, Himes BE. Airway Smooth Muscle-Specific Transcriptomic Signatures of Glucocorticoid Exposure. Am J Respir Cell Mol Biol. 2019 61(1):110-120. PMID: 30694689

Open-source tools and their applications

Kan M, Diwadkar AR, Saxena S, Shuai H, Joo J, Himes BE. REALGAR: a web app of integrated respiratory omics data. Bioinformatics. 2022 Sep 15;38(18):4442-4445. PMID: 35863045

Diwadkar AR, Kan M, Himes BE. Facilitating Analysis of Publicly Available ChIP-Seq Data for Integrative Studies. AMIA Annu Symp Proc. 2020 Mar 4;2019:371-379. Received AMIA 2019 Distinguished Paper Award. PMID: 32308830

Kan M, Shumyatcher M, Diwadkar AR, Soliman G, Himes BE. Integration of Transcriptomic Data Identifies Global and Cell-Specific Asthma-Related Gene Expression Signatures. AMIA Annu Symp Proc. 2018 Dec 5;2018:1338-1347. Finalist of AMIA Student Paper Award. PMID: 30815178

Xu Y, Zhang Y, Garcia-Canaveras JC, Guo L, Kan M, Yu S, Blair IA, Rabinowitz JD, X Yang. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 Jul 24;369(6502):397-403. PMID: 32703873

Balamuth F, Alpern ER, Kan M, Shumyatcher M, Hayes K, Lautenbach E, Himes BE. Gene Expression Profiles Differentiate Viral from Bacterial Source Pathogen in Children with Suspected Sepsis in the Emergency Department. Ann Emerg Med. 2020 Jun;75(6):744-754. PMID: 31983492

Asthma Genetics and Pharmacogenetics

Joo J, Mak ACY Mak, Xiao S, Sleiman PM, Hu D, Huntsman S, Eng C, Kan M, Diwakar AR, et al. Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness. Sci Rep. 2022 Jul 22;12(1):12514. PMID: 35869121

Dahlin A, Sordillo JE, Ziniti J, Iribarren C, Lu M, Weiss ST, Tantisira KG, Lu Q, Kan M, Himes BE, et al. Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults. J Allergy Clin Immunol 2019 143(4):1633-1635. PMID: 30578877

Panganiban R, Sun M, Dahlin A, Park H, Kan M, Himes BE, et al. A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis. J Allergy Clin Immunol. 2018 142(5):1469-1478. PMID: 29330013

NHLBI Exome Sequencing Project (ESP)

Kan M, Auer PL, Wang GT, Bucasas KL, Hooker S, Rodriguez A, Li B, Ellis J, Cupples LA, Chen YD, et al. Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project. Eur J Hum Genet. 2016 24(8):1181-7. PMID: 26757982

He Z, O’Roak BJ, Smith JD, Wang G, Hooker S, Santos-Cortez RL, Li B, Kan M, Krumm N, Nickerson DA, et al. Rare-variant extensions of the transmission disequilibrium test: application to autism exome sequence data. Am J Hum Genet. 2014 94:33-46. PMID: 24360806

Cancer Genomics and Epigenomics

Zhang L, Kan M*, Zhang M, Yu S, Xie H, Gu Z, Wang H, Zhao S, Zhou G, Song H, Zheng C. Multiregion sequencing reveals intratumor heterogeneity of driver mutations in TP53-driven non-small cell lung cancer. Int J Cancer. 2017 140(1):103-10. PMID: 27646734

Liu F, Zhou Y, Zhou D, Kan M, Niu X, Zhang Z, Zhang D, Tao L, He L, Zhang L, Liu Y. Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition. Diagnosis Pathology. 2014 9:66. PMID: 24655585

De novo genome sequencing

Wu C, Zhang D, Kan M*, Lv Z, Zhu A, et al. The draft genome of the large yellow croaker reveals well-developed innate immunity. Nat Commun. 2014 5:5227. PMID: 25407894

Genetic and Epigenetic Association Studies

Weng X, Zhang H, Kan M*, Ye J, Liu F, et al. Leukocyte telomere length is associated with advanced age-related macular degeneration in the Han Chinese population. 2015. Exp Gerontol 69:36-40. PMID: 25959250

Kan M, Weng X, Wang T, Liu F, Ye J, et al. No evidence of association between variant rs2075650 in lipid metabolism-related locus APOE/TOMM40 and advanced age-related macular degeneration in Han Chinese population. Exp Biol Med (Maywood). 2015 240:230-234. PMID: 25304313

Kan M, Liu F, Weng X, Ye J, Wang T, et al. Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population. Diagn Pathol. 2014 9:73. PMID: 24667176

Qian D, Kan M*, Weng X, Huang Y, Zhou C, et al. Common variant rs10033900 near the complement factor I gene is associated with age-related macular degeneration risk in Han Chinese population. Eur J Hum Genet. 2014 22:1417-1419. PMID: 24642830

Zheng Y, Kan M*, Yu L, Niu X, Zhou D, He L, Lu S, Liu Y. GPC5 rs2352028 polymorphism and risk of lung cancer in Han Chinese. 2012 Cancer Invest 30:13-19. PMID: 22236185

Kan MY, Zhou DZ, Zhang D, Zhang Z, Chen Z, et al. Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort. Diabet Med. 2010 27:598-602. PMID: 20536959


Kan M, Himes B. Insights into Glucocorticoid Responses Derived from Omics Studies. Pharmacol Ther. 2021 Feb;218:107674. PMID: 32910934

Kan M, Shumyatcher M, Himes B. Using omics approaches to understand pulmonary diseases. Respir Res. 2017 18(1):149. PMID: 28774304

Book Chapter

Kan M, Himes BE. Genetics and Pharmacogenetics of Asthma. Precision Therapy in Pulmonary, Critical Care and Sleep Medicine. Gomez JL, Himes BE, Kaminski N (eds). 1st ed. Springer, New York, NY. 2020. Chapter 3: 25-37p.





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